Structural and Functional MRI
With the start of the first follow-up measurement series beginning in late 2021, structural and functional MRI will be included to complement previous neurocognitive measurements. The resting-state MRI data will be recorded to quantify functional network properties and multishell diffusion-weighted imaging as well as multiparametric mapping (qMRI) to estimate the local and network architecture of gray and white matter. In addition, arterial spin labeling will be performed to quantify cerebral blood flow and magnetic resonance spectroscopy to record various parameters of brain metabolism. In the abdomen, the distribution and concentration of visceral and subcutaneous fat as well as the fat and iron concentration of the liver will be measured.