Core questions:
- Biological and environmental determinants of work ability across lifespan?
- Effects of working conditions on cognition and mental health?
- Consequences of lifestyle on brain, liver, and immune system?
- Changes in brain functions, immune and metabolic processes with increasing age?
- Links between depression, burn-out, mental performance and immune system?
- Long-term consequences of COVID-19 infection on mental functions?
- Damaging and protective factors for mental health?
Key articles

As employees age, their physical and mental abilities decline and work ability (WA) decreases, enhancing the risk for long-term sick leave or even premature retirement. However, the relative impact of biological and environmental determinants on WA with increasing age is still poorly understood in their complexity. (Gajewski et al. 2023)

Demographic changes encompass societies to maintain the work ability (WA) of aging workforces. The present study explored the relationship between modifiable lifestyle factors, cognitive functions, and their influence on WA, using a multi-group structural equation approach. (Rieker et al. 2023)

Immunological age is a biomarker extracted from the the T cells in the blood. In this study, the concept of immune age was validated and expressed as a difference between chronological and immunological age. The results show that the immune age changes with the chronological age, albeit to a different extent for each individual (Bröde et al. 2023).

Alzheimer’s disease manifests with spatial disorientation in adults at genetic risk (APOE ε4). Here we examined spatial orientation performance during a virtual navigation task in risk carriers, and found deficits decades before potential disease onset (Bierbrauer et al. 2020).