The Dortmund Vital Study is designed as a combined cross-sectional and longitudinal study. A wide range of demographic, psychological, behaviоrаl, sensory, cardiovascular, immunological, and biochemical data, a comprehensive electroencephalography (EEG)-based cognitive test battery as well as structural and functional magnetic resonance imaging (MRI) have been included in the study. The testing takes place at two days. The baseline testing was conducted between 2016 and 2021 and will be repeated every five years (three follow-up measures until 2035).